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Literature summary extracted from
- Structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycin (2007), Acta Crystallogr. Sect. F, F63, 466-470.
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 1.1.1.267 | in complex with Mg2+, NADPH, and inhibitor fosmidomycin. Protein exhibits a well-ordered conformation upon substrate binding. No electron density is observed for the nicotinamide-ribose portion of NADPH and the position of D149 anchoring Mg2+ is shifted by NADPH in the active site | Escherichia coli |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.267 | fosmidomycin | - |
Escherichia coli |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.267 | Escherichia coli | P45568 | - |
- |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.267 | NADPH | - |
Escherichia coli | |
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Release 2023.1 (January 2023)
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